When I am quire far advanced in game Running lots of trains and over 300 vehicles game fails to auto save or manual save giving the below error

Failed to write save data to 'C:\Users\Capns\AppData\Roaming\Captain of Industry\Saves\Strategic Sanctuary\1.save': Win32 IO returned 112. Path: C:\Users\Capns\AppData\Roaming\Captain of Industry\Saves\Strategic Sanctuary\1.tmp.save

Ensure that the game has access rights to the save directory and there is enough free space on the drive. Access can be blocked by antivirus software or by Windows feature called 'Controlled Folder Access'.

at System.IO.FileStream.WriteInternal (System.Byte[] src, System.Int32 offset, System.Int32 count) [0x00077] in <932fbe8ac5a946808aa5d7b95844e18c>:0
at System.IO.FileStream.Write (System.Byte[] array, System.Int32 offset, System.Int32 count) [0x00090] in <932fbe8ac5a946808aa5d7b95844e18c>:0
at Mafi.StreamExtensions.CopyToFast (System.IO.Stream fromStream, System.IO.Stream toStream) [0x00022] in <5fce48de31c24fdeb37c99c71b71bed0>:0
at Mafi.Core.SaveGame.SaveLoadFileUtils.SaveDataWithHeaders (System.UInt64 fileHeader, System.Int32 saveVersion, System.IO.Stream dataStream, System.IO.Stream outputStream, Mafi.Core.SaveGame.SaveCompressionType compression, System.Boolean skipCompressedDataChecksum, System.Boolean skipUncompressedDataChecksum) [0x000fc] in <41ba8435d492474781744046547dbc68>:0
at Mafi.Core.SaveGame.GameSaver.FinishSaveWriteToStream (System.IO.Stream outputStream) [0x0003a] in <41ba8435d492474781744046547dbc68>:0
at Mafi.Core.SaveGame.ASyncSaver.doWork (System.Object , System.ComponentModel.DoWorkEventArgs _) [0x000f8] in <41ba8435d492474781744046547dbc68>:0